Performance of orientation distribution function-fingerprinting with a biophysical multicompartment diffusion model.

ABSTRACT:

Purpose

Orientation Distribution Function (ODF) peak finding methods typically fail to reconstruct fibers crossing at shallow angles below 40°, leading to errors in tractography. ODF-Fingerprinting (ODF-FP) with the biophysical multicompartment diffusion model allows for breaking this barrier.

Methods

A randomized mechanism to generate a multidimensional ODF-dictionary that covers biologically plausible ranges of intra- and extra-axonal diffusivities and fraction volumes is introduced. This enables ODF-FP to address the high variability of brain tissue. The performance of the proposed approach is evaluated on both numerical simulations and a reconstruction of major fascicles from high- and low-resolution in vivo diffusion images.

Results

ODF-FP with the suggested modi

SUBMITTER: Filipiak P 

PROVIDER: S-EPMC9142101 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature