Spatiotemporal responses of trabecular and cortical bone to complete spinal cord injury in skeletally mature rats.

ABSTRACT:

Objective

Characterise the spatiotemporal responses of trabecular and cortical bone to complete spinal cord injury (SCI) in the skeletally mature rat in the acute (4-week) period following injury.

Methods

The spinal cord of 5-month old male rats was transected at the T9 level. Outcome measures were assessed using micro-computed tomography, three-point bending and serum markers at 1-, 2-, and 4-weeks post-transection. Comparison was made with time-0 and sham animals.

Results

Lower levels of circulating serum bone formation markers and higher bone resorption markers suggested uncoupled bone turnover as early at 1-week post-transection. Micro-computed tomography showed metaphyseal and epiphyseal trabecular bone loss was observed only at 4-weeks post-transection. The bone

SUBMITTER: Williams JA 

PROVIDER: S-EPMC9142855 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature