Histomorphometric Analysis of Differential Regional Bone Regeneration Induced by Distinct Doped Membranes.

ABSTRACT: Our objective is to evaluate the regional regenerative potential of calvarial bone in critical-sized defects in a rabbit model using novel nanostructured silica-loaded membranes doped with zinc or doxycycline. Nanostructured membranes of (MMA)₁-co-(HEMA)₁/(MA)₃-co-(HEA)₂ loaded with 5 wt% of SiO₂ nanoparticles (HOOC-Si-Membranes) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were created on six New-Zealand-breed rabbit skulls and covered with the membranes. A sham defect without a membrane was used as the control. After six weeks, a histological analysis (toluidine blue technique) was employed to determine the area percentages of newly formed bone, osteoid bone, and soft tissue.

SUBMITTER: Toledano M 

PROVIDER: S-EPMC9147672 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature