Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.

ABSTRACT:

Background

Eating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC).

Methods

A total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction.

Results

Higher attention deficit hyperactivity dis

SUBMITTER: Abdulkadir M 

PROVIDER: S-EPMC9149768 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature