High-fidelity, accelerated whole-brain submillimeter in vivo diffusion MRI using gSlider-spherical ridgelets (gSlider-SR).

ABSTRACT:

Purpose

To develop an accelerated, robust, and accurate diffusion MRI acquisition and reconstruction technique for submillimeter whole human brain in vivo scan on a clinical scanner.

Methods

We extend the ultra-high resolution diffusion MRI acquisition technique, gSlider, by allowing undersampling in q-space and radiofrequency (RF)-encoding space, thereby dramatically reducing the total acquisition time of conventional gSlider. The novel method, termed gSlider-SR, compensates for the lack of acquired information by exploiting redundancy in the dMRI data using a basis of spherical ridgelets (SR), while simultaneously enhancing the signal-to-noise ratio. Using Monte Carlo simulation with realistic noise levels and several acquisitions of in vivo human brain dMRI data (acquired

SUBMITTER: Ramos-Llorden G 

PROVIDER: S-EPMC9149785 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature