High-fidelity mesoscale in-vivo diffusion MRI through gSlider-BUDA and circular EPI with S-LORAKS reconstruction.

ABSTRACT:

Purpose

To develop a high-fidelity diffusion MRI acquisition and reconstruction framework with reduced echo-train-length for less T₂* image blurring compared to typical highly accelerated echo-planar imaging (EPI) acquisitions at sub-millimeter isotropic resolution.

Methods

We first proposed a circular-EPI trajectory with partial Fourier sampling on both the readout and phase-encoding directions to minimize the echo-train-length and echo time. We then utilized this trajectory in an interleaved two-shot EPI acquisition with reversed phase-encoding polarity, to aid in the correction of off-resonance-induced image distortions and provide complementary k-space coverage in the missing partial Fourier regions. Using model-based reconstruction with structured low-rank co

SUBMITTER: Liao C 

PROVIDER: S-EPMC10451786 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature