In vivo microscopic diffusional kurtosis imaging with symmetrized double diffusion encoding EPI.

ABSTRACT:

Purpose

Diffusional kurtosis imaging (DKI) measures the deviation of the displacement probability from a normal distribution, complementing the data commonly acquired by diffusion MRI. It is important to elucidate the sources of kurtosis contrast, particularly in biological tissues where microscopic kurtosis (intrinsic kurtosis) and diffusional heterogeneity may co-exist.

Methods

We have developed a technique for microscopic kurtosis MRI, dubbed microscopic diffusional kurtosis imaging (µDKI), using a symmetrized double diffusion encoding (s-DDE) EPI sequence. We compared this newly developed µDKI to conventional DKI methods in both a triple compartment phantom and in vivo.

Results

Our results showed that whereas conventional DKI and µDKI provided similar measurements

SUBMITTER: Ji Y 

PROVIDER: S-EPMC6258297 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature