Adiponectin, Leptin, and Resistin and the Risk of Dementia.

ABSTRACT:

Background

Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia.

Methods

We performed a case-cohort study embedded in the prospective, population-based Rotterdam Study. Plasma levels of the adiponectin, leptin, and resistin were measured at baseline (1997-1999) in a random subcohort of 945 participants without dementia, and additionally in 177 participants, who were diagnosed with dementia during follow-up (until January 1, 2018).

Results

SUBMITTER: Mooldijk SS 

PROVIDER: S-EPMC9159665 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature