α-Catenin links integrin adhesions to F-actin to regulate ECM mechanosensing and rigidity dependence.

ABSTRACT: Both cell-cell and cell-matrix adhesions are regulated by mechanical signals, but the mechanobiological processes that mediate the cross talk between these structures are poorly understood. Here we show that α-catenin, a mechanosensitive protein that is classically linked with cadherin-based adhesions, associates with and regulates integrin adhesions. α-Catenin is recruited to the edges of mesenchymal cells, where it interacts with F-actin. This is followed by mutual retrograde flow of α-catenin and F-actin from the cell edge, during which α-catenin interacts with vinculin within integrin adhesions. This interaction affects adhesion maturation, stress-fiber assembly, and force transmission to the matrix. In epithelial cells, α-catenin is present in cell-cell adhesions and absent from cell-

SUBMITTER: Mukherjee A 

PROVIDER: S-EPMC9166284 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature