Distinct Glycosylation Responses to Spinal Cord Injury in Regenerative and Nonregenerative Models.

ABSTRACT: Traumatic spinal cord injury (SCI) results in disruption of tissue integrity and loss of function. We hypothesize that glycosylation has a role in determining the occurrence of regeneration and that biomaterial treatment can influence this glycosylation response. We investigated the glycosylation response to spinal cord transection in Xenopus laevis and rat. Transected rats received an aligned collagen hydrogel. The response compared regenerative success, regenerative failure, and treatment in an established nonregenerative mammalian system. In a healthy rat spinal cord, ultraperformance liquid chromatography (UPLC) N-glycoprofiling identified complex, hybrid, and oligomannose N-glycans. Following rat SCI, complex and outer-arm fucosylated glycans decreased while oligomannose and hy

SUBMITTER: Ronan R 

PROVIDER: S-EPMC9171824 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature