Performance of a Multianalyte 'Rule-Out' Assay in Pregnant Individuals With Suspected Preeclampsia.

ABSTRACT:

Background

The ability to diagnose preeclampsia clinically is suboptimal. Our objective was to validate a novel multianalyte assay and characterize its performance, when intended for use as an aid to rule-out preeclampsia.

Methods

Prospective, multicenter cohort study of pregnant individuals presenting between 28^0/7 and 36^6/7 weeks' with preeclampsia-associated signs and symptoms. Individuals not diagnosed with preeclampsia after baseline evaluation were enrolled in the study cohort, with those who later developed preeclampsia, classified as cases and compared with a negative control group who did not develop preeclampsia. Individuals with assay values at time of enrollment ≥0.0325, determined using a previously developed algorithm, considered at risk.

SUBMITTER: Costantine MM 

PROVIDER: S-EPMC9172903 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature