An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

ABSTRACT: Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients¹. Both the number of transferred T cells and their differentiation state are critical determinants of effective responses^2,3. T cells can be expanded with T cell receptor (TCR)-mediated stimulation and interleukin-2, but this can lead to differentiation into effector T cells^4,5 and lower therapeutic efficacy⁶, whereas maintenance of a more stem-cell-like state before adoptive transfer is beneficial⁷. Here we show that H9T, an engineered interleukin-2 partial agonist, promotes the expansion of CD8⁺ T cells without driving terminal differentiation. H9T led to altered STAT5 signalling

SUBMITTER: Mo F 

PROVIDER: S-EPMC9172917 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature