Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells.
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ABSTRACT:
SUBMITTER: Hnit SST
PROVIDER: S-EPMC9174405 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Apigenin impedes cell cycle progression at G<sub>2</sub> phase in prostate cancer cells.
Hnit Su Su Thae SST Yao Mu M Xie Chanlu C Bi Ling L Wong Matthew M Liu Tao T De Souza Paul P Li Zhong Z Dong Qihan Q
Discover oncology 20220607 1
As a natural flavone, apigenin is abundantly present in vegetables, fruits, oregano, tea, chamomile, wheat sprout and is regarded as a major component of the Mediterranean diet. Apigenin is known to inhibit proliferation in different cancer cell lines by inducing G<sub>2</sub>/M arrest, but it is unclear whether this action is predominantly imposed on G<sub>2</sub> or M phases. In this study, we demonstrate that apigenin arrests prostate cancer cells at G<sub>2</sub> phase by flow cytometric ana ...[more]
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