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Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).


ABSTRACT: Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters that serve a role in regulating normal and pathological cellular activities. They can stimulate or inhibit cancer cell proliferation and invasion, as well as interfere with cancer cell responses to drug treatments. Understanding the molecular pathways governing the interactions between these gases and the tumor microenvironment can be utilized for the identification of a novel technique to disrupt cancer cell interactions and may contribute to the conception of effective and safe cancer therapy strategies. The present review discusses the effects of these gases in modulating the action of chemotherapies, as well as prospective pharmacological and therapeutic interfering approaches. A deeper knowledge of the mechanisms that underpin the cellular and pharmacological effects, as well as interactions, of each of the three gases could pave the way for therapeutic treatments and translational research.

SUBMITTER: Salihi A 

PROVIDER: S-EPMC9178674 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).

Salihi Abbas A   Al-Naqshabandi Mohammed A MA   Khudhur Zhikal Omar ZO   Housein Zjwan Z   Hama Harmand A HA   Abdullah Ramyar M RM   Hussen Bashdar Mahmud BM   Alkasalias Twana T  

Molecular medicine reports 20220526 1


Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters that serve a role in regulating normal and pathological cellular activities. They can stimulate or inhibit cancer cell proliferation and invasion, as well as interfere with cancer cell responses to drug treatments. Understanding the molecular pathways governing the interactions between these gases and the tumor microenvironment can be utilized for the identification of a novel technique to disrupt cancer cel  ...[more]

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