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Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents.

ABSTRACT: Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Aryl carbamates with the oxamate moiety were selectively anti-proliferative for the cancer cell lines tested, while the aryl ureas were inactive. In the cytoprotection studies, the same aryl carbamates were able to counteract the CoCl2 cytotoxicity by 3-8%. The possible molecular targets of the aryl carbamates during the anti-proliferative action were the adenosine A2 receptor and CDK2. The obtained results are promising for the development of novel anti-cancer therapeutics.

SUBMITTER: Oshchepkov M 

PROVIDER: S-EPMC9182529 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents.

Oshchepkov Maxim M   Kovalenko Leonid L   Kalistratova Antonida A   Ivanova Maria M   Sherstyanykh Galina G   Dudina Polina P   Antonov Alexey A   Cherkasova Anastasia A   Akimov Mikhail M  

Molecules (Basel, Switzerland) 20220604 11

Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H<sub>2</sub>O<sub>2</sub> and CoCl<sub>2</sub> models. Aryl carbamates with the oxamate moiety were selectively anti-proliferative for the cancer cell  ...[more]

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