Empirical assessment of allele frequencies of genome wide association study variants associated with obstructive sleep apnea.

ABSTRACT:

Objective

Obstructive Sleep Apnea (OSA) is a heterogeneous disorder with a complex interplay of genetic and environmental factors. Over the years, with advancement in genotyping and sequencing techniques, various loci have shown an association with OSA. It is pertinent to understand the status of these associated variants in different ethnic groups. The aim of the study was to assess the genetic affinity among different population groups by evaluating the risk allele frequencies of variants associated with OSA.

Method

The variants associated with OSA were obtained from the GWAS catalog with a significant p value of <5 × 10^-7; 95 variants were obtained (www.ebi.ac.uk/gwas). Further, the variants were narrowed down on the basis of risk allele frequencies (>5%

SUBMITTER: Mohit 

PROVIDER: S-EPMC9185076 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature