Lower limb bone geometry in adult individuals with X-linked hypophosphatemia: an observational study.

ABSTRACT: We assessed lower-limb geometry in adults with X-linked hypophosphatemia (XLH) and controls. We found large differences in multiple measures including femoral and tibial torsion, bowing and cross-sectional area and acetabular version and coverage which may contribute to clinical problems such as osteoarthritis, fractures and altered gait common in XLH.

Purpose

Individuals with X-linked hypophosphatemia (XLH) are at risk of lower-limb deformities and early onset of osteoarthritis. These two factors may be linked, as altered biomechanics is a risk factor for osteoarthritis. This exploratory evaluation aims at providing clues and concepts for this association to facilitate future larger-scale and longitudinal studies on that aspect.

Methods

For this observational study, 13 patie

SUBMITTER: Scorcelletti M 

PROVIDER: S-EPMC9187561 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature