Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study.

ABSTRACT:

Objectives

To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with clinical characteristics.

Design

Individual patient level data meta-analysis and modelling study.

Setting

Fourteen studies from 13 countries, including randomised controlled trials and prospective observational studies.

Participants

Individual patient level data for 10 369 patients with suspected acute heart failure were pooled for the meta-analysis to evaluate NT-proBNP thresholds. A decision support tool (Collaboration for the Diagnosis and Evaluation of Heart Failure (CoDE-HF)) that combines NT-proBNP with clinical variables

SUBMITTER: Lee KK 

PROVIDER: S-EPMC9189738 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature