Dataset Information

A Novel Approach to Maintain Physiological Ketosis During Intermittent Fasting With the Consumption of a Fast BarTM and Coffee or Tea: a Randomized, Controlled Study

ABSTRACT: Abstract

Objectives

Intermittent fasting has gained popularity in promoting health and been proposed to combat metabolic diseases. The study aimed to evaluate the effects of consuming a Fast BarTM (FB) with coffee or tea in extending physiological ketosis associated with time-restricted eating (Clinicaltrial.gov: NCT04790552).

Methods

We conducted the study remotely during the COVID-19 pandemic with healthy adults. Participants were randomized into 4 groups: water-only fast (overnight for 15 hours), FB as a nighttime snack, FB + coffee or FB + tea in the morning. Blood ketone (BHB) and glucose levels were measured hourly for 4 hours (Precision Xtra Blood Ketone & Glucose Monitoring System, Abbott) after consuming study foods. Subjects also completed a satiety and mood survey.

Results

84 of the 89 enrolled participants completed the study. There was no postprandial glucose increase after consuming the Fast Bar with either black coffee or tea. The mean (SD) BHB AUC0–4 for nighttime FB, FB + coffee, FB + tea, or water-only fast were 1.40 (0.81), 1.22 (0.73), 1.11 (0.45), 1.36 (0.78) mM∙h, respectively. Despite a delay in BHB increase 1 hour after consuming the Fast Bar, the 4-h ketone and glucose AUCs of the Fast Bar groups were similar to those of subjects water-fasted for 19 hours (one-way ANOVA with Dunn's multiple comparison test).

Conclusions

Fast BarTM can be used as a nighttime snack, or with coffee or tea in the morning, to extend physiologic fasting state comparable to a 19-h water fasting. Fast BarTM may be used to support intermittent fasting or time-restricted eating pattern while providing satiety.

Funding Sources

Fully funded by L-Nutra, Inc.

SUBMITTER:

PROVIDER: S-EPMC9193771 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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