IL-33 and the PKA Pathway Regulate ILC2 Populations Expressing IL-9 and ST2.

ABSTRACT: Type 2 Innate lymphoid cells (ILC2s) are tissue-resident immune cells activated by epithelial-derived alarmins upon tissue damage. They regulate immunity against helminth parasites and allergies by expressing type 2 immune response cytokines including IL-9, known to be critical for inducing and potentiating the immune response in such context. Although ILC2s are reported to be the main source of IL-9 in mice during N. brasiliensis infection, the mechanisms that regulate the expression of IL-9 in these cells are yet to be described. Recent studies have shown that in addition to cytokines, multiple molecules can differentially modulate the functions of ILC2s in various contexts both in vitro and in vivo. Among these stimuli are lipid mediators and neuropeptides, which ac

SUBMITTER: Olguin-Martinez E 

PROVIDER: S-EPMC9197159 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature