Identification of Heparan Sulfate in Dilated Cardiomyopathy by Integrated Bioinformatics Analysis.

ABSTRACT:

Objectives

Heparan sulfate (HS) forms heparan sulfate proteoglycans (HSPGs), such as syndecans (SDCs) and glypicans (GPCs), to perform biological processes in the mammals. This study aimed to explore the role of HS in dilated cardiomyopathy (DCM).

Methods

Two high throughput RNA sequencing, two microarrays, and one single-cell RNA sequencing dataset of DCM hearts were downloaded from the Gene Expression Omnibus (GEO) database and integrated for bioinformatics analyses. Differential analysis, pathway enrichment, immunocytes infiltration, subtype identification, and single-cell RNA sequencing analysis were used in this study.

Results

The expression level of most HSPGs was significantly upregulated in DCM and was closely associated with immune activation, cardiac fibrosi

SUBMITTER: Song W 

PROVIDER: S-EPMC9197211 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature