Animal Models of Cardiovascular Complications of Pregnancy.

ABSTRACT: Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.

SUBMITTER: Arany Z 

PROVIDER: S-EPMC9199836 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature