RS1 gene is a novel prognostic biomarker for lung adenocarcinoma.

ABSTRACT:

Background

Although it has a poor prognosis, patients with lung adenocarcinoma (LUAD) have a relatively higher 5-year survival period. Thus, it is necessary to identify effective prognostic markers to evaluate the effect of early treatment. RS1 gene encodes retinoschisin, a key protein in congenital retinoschisis, while few studies have been reported on the association between RS1 and cancer prognosis.

Methods

We performed bioinformatic analyses based on the data obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases to demonstrate the expression level of RS1 was related to the LUAD prognosis and our findings were verified in-vitro and clinical samples. Then, we explored the potential mechanism of how RS1 expression influenced the prognosis of LUAD.

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SUBMITTER: Zhang T 

PROVIDER: S-EPMC9200886 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature