Dataset Information

RS1 gene is a novel prognostic biomarker for lung adenocarcinoma.

ABSTRACT:

Background

Although it has a poor prognosis, patients with lung adenocarcinoma (LUAD) have a relatively higher 5-year survival period. Thus, it is necessary to identify effective prognostic markers to evaluate the effect of early treatment. RS1 gene encodes retinoschisin, a key protein in congenital retinoschisis, while few studies have been reported on the association between RS1 and cancer prognosis.

Methods

We performed bioinformatic analyses based on the data obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases to demonstrate the expression level of RS1 was related to the LUAD prognosis and our findings were verified in-vitro and clinical samples. Then, we explored the potential mechanism of how RS1 expression influenced the prognosis of LUAD.

Results

Compared with normal tissues, the RS1 expression was significantly lower in tumor tissues. The Multivariate Cox regression model showed that RS1 could be used as an independent prognostic indicator. Furthermore, we found significant differences in immune cell infiltration between RS1 high and low expression groups, and the proteasome pathway was found enriched in RS1 low expression samples.

Conclusion

In conclusion, our study suggests that RS1 is a novel prognostic biomarker for LUAD. Differences in immune cell infiltration and signaling pathways may contribute to the poor prognosis of LUAD caused by low RS1 expression.

SUBMITTER: Zhang T

PROVIDER: S-EPMC9200886 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

RS1 gene is a novel prognostic biomarker for lung adenocarcinoma.

Zhang Tao T Cheng Guowei G Chen Ping P Peng Yue Y Liu Lei L Li Runze R Qiu Bin B

Thoracic cancer 20220515 12

<h4>Background</h4>Although it has a poor prognosis, patients with lung adenocarcinoma (LUAD) have a relatively higher 5-year survival period. Thus, it is necessary to identify effective prognostic markers to evaluate the effect of early treatment. RS1 gene encodes retinoschisin, a key protein in congenital retinoschisis, while few studies have been reported on the association between RS1 and cancer prognosis.<h4>Methods</h4>We performed bioinformatic analyses based on the data obtained from The ...[more]

PMID: 35569920

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Dataset Information

RS1 gene is a novel prognostic biomarker for lung adenocarcinoma.

Background

Methods

Results

Conclusion

Publications

RS1 gene is a novel prognostic biomarker for lung adenocarcinoma.

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