Notopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat.

ABSTRACT:

Introduction

Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none of these have reversed the ongoing remodeling of blood vessels. Considering notopterol, a linear furocoumarin extracted from the root of traditional Chinese medicine Qiang-Huo (Notopterygium incisum), had shown the antiproliferative and anti-inflammatory properties in previous studies, we hypothesized that it could play a role in ameliorating PAH.

Methods

In vivo, we conducted monocrotaline (MCT) induced PAH rats and treated them with notopterol for 3 weeks. Then, the rats were examined by echocardiography and RV catheterization. The heart and lung specimens were harvested for the detection of gross

SUBMITTER: Huang L 

PROVIDER: S-EPMC9203832 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature