Probing Cerebral Metabolism with Hyperpolarized ¹³C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound.

ABSTRACT: Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to promote the local delivery of hyperpolarized substrates. In this study, we investigated the effects of FUS on imaging brain metabolism using two hyperpolarized ¹³C-labeled substrates in rodents: [1-¹³C]pyruvate and [1-¹³C]glycerate. The BBB is a rate-limiting factor for pyruvate delivery to the brain, and glycerate minimally passes through the BBB. First, cerebral imaging with hyperpolarized [1-¹³C]pyruvate resulted in an increase in total ¹³C signals (p = 0.05) after disrupting the BBB with FUS. Signific

SUBMITTER: Hackett EP 

PROVIDER: S-EPMC9205167 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature