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I₂-mediated Csp²-P bond formation via tandem cyclization of o-alkynylphenyl isothiocyanates with organophosphorus esters.

ABSTRACT: A novel, I₂-mediated tandem cyclization of o-alkynylphenyl isothiocyanates with organophosphorus esters has been developed under mild conditions. Different kinds of 4H-benzo[d][1,3]thiazin-2-ylphosphonate could be synthesized in moderate to excellent yields. This method has the advantages of easy access to raw materials, free-metal catalyst, simple operation, high yield and high functional group tolerance.

SUBMITTER: Liu Y

PROVIDER: S-EPMC9207709 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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I2-mediated Csp2-P bond formation via tandem cyclization of o-alkynylphenyl isothiocyanates with organophosphorus esters.

Liu Yang Y Wu Wenjin W Sang Xiaoyan X Xia Yu Y Fang Guojian G Hao Wenyan W

RSC advances 20220620 28

A novel, I2-mediated tandem cyclization of o-alkynylphenyl isothiocyanates with organophosphorus esters has been developed under mild conditions. Different kinds of 4H-benzo[d][1,3]thiazin-2-ylphosphonate could be synthesized in moderate to excellent yields. This method has the advantages of easy access to raw materials, free-metal catalyst, simple operation, high yield and high functional group tolerance. ...[more]

PMID: 35800309

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