Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.

ABSTRACT: The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer's Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceler

SUBMITTER: Milicic L 

PROVIDER: S-EPMC9213584 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature