Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker.

ABSTRACT:

Background

Exposure to ambient fine particulate matter (PM_2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM_2.5 are highly hazardous; however, the contribution of PM_2.5-bound PAHs to PM_2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some PM_2.5-bound PAHs activate the aryl hydrocarbon receptor (AhR). The present study investigated whether the AhR pathway is involved in the mechanism of PM_2.5-induced vascular toxicity, identified the PAH in PM_2.5 that was the major contributor of AhR activation, and identified a biomarker for vascular toxicity of PM_2.5-bound PAHs.

Results

Treatment

SUBMITTER: Ho CC 

PROVIDER: S-EPMC9219152 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature