Multifunctional Hybrid MoS₂-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine.

ABSTRACT: In this work, flower-like molybdenum disulfide (MoS₂) microspheres were produced with polyethylene glycol (PEG) to form MoS₂-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS₂-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS₂-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS₂-PEG and MoS₂-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.

SUBMITTER: Malagrino TRS 

PROVIDER: S-EPMC9227389 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature