Dataset Information

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.

ABSTRACT:

Background

The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.

Methods

We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.

Results

During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).

Conclusions

The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.

SUBMITTER: Nimptsch K

PROVIDER: S-EPMC9229883 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.

Nimptsch Katharina K Aleksandrova Krasimira K Fedirko Veronika V Jenab Mazda M Gunter Marc J MJ Siersema Peter D PD Wu Kana K Katzke Verena V Kaaks Rudolf R Panico Salvatore S Palli Domenico D May Anne M AM Sieri Sabina S Bueno-de-Mesquita Bas B Standahl Karina K Sánchez Maria-Jose MJ Perez-Cornago Aurora A Olsen Anja A Tjønneland Anne A Bonet Catalina Bonet CB Dahm Christina C CC Chirlaque María-Dolores MD Fiano Valentina V Tumino Rosario R Gurrea Aurelio Barricarte AB Boutron-Ruault Marie-Christine MC Menegaux Florence F Severi Gianluca G van Guelpen Bethany B Lee Young-Ae YA Pischon Tobias T

BMC cancer 20220624 1

<h4>Background</h4>The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.<h4>Methods</h4>We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort u ...[more]

PMID: 35739525

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Dataset Information

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.

Background

Methods

Results

Conclusions

Publications

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.

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