Functional associations between polymorphic regions of the human 3'IgH locus and COVID-19 disease.

ABSTRACT:

Purpose

The pandemic diffusion of Coronavirus Disease 2019 (COVID-19) has highlighted significant gender-related differences in disease severity. Despite several hypotheses being proposed, how the genetic background of COVID-19 patients might impact clinical outcomes remains largely unknown.

Methods

We collected blood samples from 192 COVID-19 patients (115 men, 77 women, mean age 67 ± 19 years) admitted between March and June 2020 at two different hospital centers in Italy, and determined the allelic distribution of nine Single Nucleotide Polymorphisms (SNPs), located at the 3'Regulatory Region (3'RR)-1 in the immunoglobulin (Ig) heavy chain locus, including *1 and *2 alleles of polymorphic hs1.2 enhancer region.

Results

In COVID-19 patients, the genotyped SNPs exhib

SUBMITTER: Colucci M 

PROVIDER: S-EPMC9241982 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature