Bacteroides ovatus-mediated CD27^- MAIT cell activation is associated with obesity-related T2D progression.

ABSTRACT: Type 2 diabetes (T2D) is highly associated with obesity. However, the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial metabolites, have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity. By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D, we found an elevation in CD27-negative (CD27^-) MAIT cells producing a high level of IL-17 under T2D obese conditions, which could be positively correlated with impaired glucose metabolism in obese people. We furthe

SUBMITTER: Li Y 

PROVIDER: S-EPMC9243016 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature