Complex Feline Disease Mapping Using a Dense Genotyping Array.
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ABSTRACT:
SUBMITTER: Hernandez I
PROVIDER: S-EPMC9244801 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Complex Feline Disease Mapping Using a Dense Genotyping Array.
Hernandez Isabel I Hayward Jessica J JJ Brockman Jeff A JA White Michelle E ME Mouttham Lara L Wilcox Elizabeth A EA Garrison Susan S Castelhano Marta G MG Loftus John P JP Gomes Filipe Espinheira FE Balkman Cheryl C Brooks Marjory B MB Fiani Nadine N Forman Marnin M Kern Tom T Kornreich Bruce B Ledbetter Eric C EC Peralta Santiago S Struble Angela M AM Caligiuri Lisa L Corey Elizabeth E Lin Lin L Jordan Julie J Sack Danny D Boyko Adam R AR Lyons Leslie A LA Todhunter Rory J RJ
Frontiers in veterinary science 20220616
The current feline genotyping array of 63 k single nucleotide polymorphisms has proven its utility for mapping within breeds, and its use has led to the identification of variants associated with Mendelian traits in purebred cats. However, compared to single gene disorders, association studies of complex diseases, especially with the inclusion of random bred cats with relatively low linkage disequilibrium, require a denser genotyping array and an increased sample size to provide statistically si ...[more]
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