Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.

ABSTRACT: The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

SUBMITTER: Coverdale JPC 

PROVIDER: S-EPMC9244874 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature