Functional cargos of exosomes derived from Flk-1⁺ vascular progenitors enable neurulation and ameliorate embryonic anomalies in diabetic pregnancy.

ABSTRACT: Various types of progenitors initiate individual organ formation and their crosstalk orchestrates morphogenesis for the entire embryo. Here we show that progenitor exosomal communication across embryonic organs occurs in normal development and is altered in embryos of diabetic pregnancy. Endoderm fibroblast growth factor 2 (FGF2) stimulates mesoderm Flk-1⁺ vascular progenitors to produce exosomes containing the anti-stress protein Survivin. These exosomes act on neural stem cells of the neuroepithelium to facilitate neurulation by inhibiting cellular stress and apoptosis. Maternal diabetes causes Flk-1⁺ progenitor dysfunction by suppressing FGF2 through DNA hypermethylation. Restoring endoderm FGF2 prevents diabetes-induced survivin reduction in Flk-1⁺ prog

SUBMITTER: Cao S 

PROVIDER: S-EPMC9249756 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature