Dataset Information

SLC12A3 Variation and Renal Function in Chinese Patients With Hypertension.

ABSTRACT:

Objective

SLC12A3 (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. We aimed to investigate the association between SLC12A3 gene polymorphisms and renal function in patients with hypertension.

Methods

Participants from three non-diabetic hypertensive cohorts, including young-onset hypertension (cohort 1, n = 882), treatment-naïve hypertension (cohort 2, n = 90), and follow-up cohort (cohort 3, n = 166), underwent genotyping for single nucleotide polymorphisms in SLC12A3. Renal events were defined as a >25 and >50% decline in estimated glomerular filtration rate (eGFR).

Results

In cohort 1, SLC12A3 rs16963397 C/C or C/G (P = 0.005), rs13334864 C/C or C/T (P = 0.020), and rs7187932 A/A or A/G polymorphisms (P = 0.014) had higher eGFRs compared to their counterparts, with similar findings observed in cohort 2. In cohort 3, over a mean follow-up of 5.8 ± 1.7 years, participants with either SLC12A3 rs16963397 C/C or rs13334864 C/C polymorphisms had more >25 and >50% eGFR decline than their counterparts (log-rank test, P = 0.058 and P = 0.038, respectively). Cox regression analysis revealed that SLC12A3 rs16963397 C/C and rs13334864 C/C polymorphisms were significantly associated with an increased risk of >25% [hazard ratio (HR), 3.294; 95% confidence interval (CI), 1.158-9.368; P = 0.025] and >50% decline in eGFR (HR, 18.630; 95% CI, 1.529-227.005, P = 0.022) than their counterparts.

Conclusion

SLC12A3 polymorphisms are associated with renal function in Chinese patients with hypertension.

SUBMITTER: Huang CC

PROVIDER: S-EPMC9253539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

<i>SLC12A3</i> Variation and Renal Function in Chinese Patients With Hypertension.

Huang Chin-Chou CC Chung Chia-Min CM Yang Chih-Yu CY Leu Hsin-Bang HB Huang Po-Hsun PH Lin Liang-Yu LY Wu Tao-Cheng TC Lin Shing-Jong SJ Pan Wen-Harn WH Chen Jaw-Wen JW

Frontiers in medicine 20220621

<h4>Objective</h4><i>SLC12A3</i> (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. We aimed to investigate the association between <i>SLC12A3</i> gene polymorphisms and renal function in patients with hypertension.<h4>Methods</h4>Participants from three non-diabetic hypertensive cohorts, including young-onset hypertension (cohort 1, <i>n</i> = 882), treatment-naïve hypertension (co ...[more]

PMID: 35801212

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