Specific miRNAs Change After 3 Months of GH treatment and Contribute to Explain the Growth Response After 12 Months.

ABSTRACT:

Context

There is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.

Objective

The aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.

Design and methods

The expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t-3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or <-1.5 at t+3 were considered as differentially expressed. In silico analysis of target genes and pathways led to a validati

SUBMITTER: Catellani C 

PROVIDER: S-EPMC9256936 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature