Clinical outcomes and quantitative CT analysis after bronchoscopic lung volume reduction using valves for advanced emphysema.

ABSTRACT:

Background

Bronchoscopic lung volume reduction (BLVR) using Zephyr endobronchial valve (EBV) and intrabronchial valve (IBV) has been shown to improve lung function and exercise capacity in severe emphysema. However, changes in airway structures and whether these are related to the clinical improvements remain unclear.

Methods

A retrospective study was performed on patients treated with BLVR. We compared changes in 2nd-, 3rd-, and 4th-generation bronchial structures after therapy, including wall thickness (WT), percentage of wall thickness (WT%), intraluminal area (LA), wall area (WA), and WA%. Responder and non-responder subgroup analysis according to minimum clinically important difference (MCID) which was defined as an improvement of 15% in forced expiratory volume in 1 s

SUBMITTER: Guo F 

PROVIDER: S-EPMC9264089 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature