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Lifespan associations of resting-state brain functional networks with ADHD symptoms


ABSTRACT: Summary Attention-deficit/hyperactivity disorder (ADHD) is increasingly being diagnosed in both children and adults, but the neural mechanisms that underlie its distinct symptoms and whether children and adults share the same mechanism remain poorly understood. Here, we used a nested-spectral partition approach to study resting-state brain networks of ADHD patients (n = 97) and healthy controls (HCs, n = 97) across the lifespan (7–50 years). Compared to the linear lifespan associations of brain segregation and integration with age in HCs, ADHD patients have a quadratic association in the whole-brain and in most functional systems, whereas the limbic system dominantly affected by ADHD has a linear association. Furthermore, the limbic system better predicts hyperactivity, and the salient attention system better predicts inattention. These predictions are shared in children and adults with ADHD. Our findings reveal a lifespan association of brain networks with ADHD and provide potential shared neural bases of distinct ADHD symptoms in children and adults. Graphical abstract Highlights • ADHD patients have a quadratic association with age in brain functional networks• Limbic system better predicts hyperactivity across the lifespan• Salient attention system better predicts the inattention across the lifespan• The predictions on symptom scores are shared in ADHD children and adults Biological sciences; Neuroscience; Developmental neuroscience; Cognitive neuroscience

SUBMITTER: Wang R 

PROVIDER: S-EPMC9272385 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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