Relationship between tool-like receptor 4 gene polymorphism and the susceptibility to pulmonary tuberculosis.

ABSTRACT:

Objective

To evaluate the susceptibility of pulmonary tuberculosis based on the single nucleotide polymorphism (SNP) of Toll like receptor 4 (TLR4) gene.

Methods

We searched PubMed, Web of science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases using mesh words: "tuberculosis", "pulmonary", "TLR4", "SNP", "Toll like receptor 4", "nucleotide polymorphism" for studies on the relations between TLR4 SNP polymorphism and the risk of pulmonary tuberculosis that were published before September 1^st, 2021. Papers were selected according to the inclusion and exclusion criteria established in advance. The allele and genotype data of the four most widely studied SNP loci (rs4986791, rs4986790, rs11536889, rs10759932) in TLR4 gene were extracted and ana

SUBMITTER: Muheremu A 

PROVIDER: S-EPMC9274595 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature