Profiling vitamin D, its mediators and proinflammatory cytokines in rheumatoid arthritis: A case–control study

ABSTRACT: Abstract

Introduction

The active form of vitamin D has immunomodulatory and anti‐inflammatory effect. Vitamin D is implicated in pathogenesis of rheumatoid arthritis (RA) and its deficiency leads to increased inflammation. Moreover, its production is dependent on concentration of calcium, phosphorus, and parathyroid hormone (PTH). Cytokines mediates inflammation in RA synovium. This study evaluated vitamin D, its mediators and proinflammatory cytokines among RA patients.

Methods

In a case–control study, 78 RA patients from Komfo Anokye Teaching Hospital rheumatology clinic and 60 healthy blood donors were recruited. Chemistry analyzer and enzyme‐linked immunosorbent assay kits were used to measure biochemical parameters and cytokines.

Results

We found significant

SUBMITTER: Sakyi S 

PROVIDER: S-EPMC9274797 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature