Dataset Information

Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study.

ABSTRACT:

Purpose

Caffeinated beverages are consumed daily throughout the world. Caffeine consumption has been linked to dysfunction of the autonomic nervous system. However, the exact effects are still insufficiently understood.

Methods

Sixteen healthy individuals were included in the present non-randomized cross-over interventional study. All study subjects consumed a commercial energy drink (containing 240 mg caffeine), and in a second independent session coffee (containing 240 mg caffeine). High-resolution digital ECGs in Frank-lead configuration were recorded at baseline before consumption, and 45 min after consumption of the respective beverage. Using customized software, we assessed ECG-based biomarker periodic repolarization dynamics (PRD), which mirrors the effect of efferent cardiac sympathetic activity on the ventricular myocardium.

Results

The consumption of energy drinks resulted in an increase in PRD levels (3.64 vs. 5.85 deg²; p < 0.001). In contrast, coffee consumption did not alter PRD levels (3.47 vs 3.16 deg², p = 0.63). The heart rates remained unchanged both after coffee and after energy drink consumption. Spearman analysis showed no significant correlation between PRD changes and heart rate changes (R = 0.34, p = 0.31 for coffee, R = 0.31, p = 0.24 for energy drink).

Conclusion

Our data suggests that sympathetic activation after consumption of caffeinated beverages is independent from caffeine and might be mediated by other substances.

Trial number

NCT04886869, 13 May 2021, retrospectively registered.

SUBMITTER: Schuttler D

PROVIDER: S-EPMC9279225 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study.

Schüttler Dominik D Rudi Wolf-Stephan WS Bauer Axel A Hamm Wolfgang W Brunner Stefan S

European journal of nutrition 20220310 5

<h4>Purpose</h4>Caffeinated beverages are consumed daily throughout the world. Caffeine consumption has been linked to dysfunction of the autonomic nervous system. However, the exact effects are still insufficiently understood.<h4>Methods</h4>Sixteen healthy individuals were included in the present non-randomized cross-over interventional study. All study subjects consumed a commercial energy drink (containing 240 mg caffeine), and in a second independent session coffee (containing 240 mg caffei ...[more]

PMID: 35266046

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Project description:BackgroundEnhanced sympathetic activity at the ventricular myocardium can destabilize repolarization, increasing the risk of death. Sympathetic activity is known to cluster in low-frequency bursts; therefore, we hypothesized that sympathetic activity induces periodic low-frequency changes of repolarization. We developed a technique to assess the sympathetic effect on repolarization and identified periodic components in the low-frequency spectral range (≤0.1 Hz), which we termed periodic repolarization dynamics (PRD).MethodsWe investigated the physiological properties of PRD in multiple experimental studies, including a swine model of steady-state ventilation (n=7) and human studies involving fixed atrial pacing (n=10), passive head-up tilt testing (n=11), low-intensity exercise testing (n=11), and beta blockade (n=10). We tested the prognostic power of PRD in 908 survivors of acute myocardial infarction (MI). Finally, we tested the predictive values of PRD and T-wave alternans (TWA) in 2,965 patients undergoing clinically indicated exercise testing.ResultsPRD was not related to underlying respiratory activity (P<0.001) or heart-rate variability (P=0.002). Furthermore, PRD was enhanced by activation of the sympathetic nervous system, and pharmacological blockade of sympathetic nervous system activity suppressed PRD (P≤0.005 for both). Increased PRD was the strongest single risk predictor of 5-year total mortality (hazard ratio 4.75, 95% CI 2.94-7.66; P<0.001) after acute MI. In patients undergoing exercise testing, the predictive value of PRD was strong and complementary to that of TWA.ConclusionWe have described and identified low-frequency rhythmic modulations of repolarization that are associated with sympathetic activity. Increased PRD can be used as a predictor of mortality in survivors of acute MI and patients undergoing exercise testing.Trial registrationClinicalTrials.gov NCT00196274.FundingThis study was funded by Angewandte Klinische Forschung, University of Tübingen (252-1-0).

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Dataset Information

Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study.

Purpose

Methods

Results

Conclusion

Trial number

Publications

Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study.

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