Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates.

ABSTRACT: Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates.

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9280444 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature