Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates.
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ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC9280444 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Turn-on fluorescent sensors for Cu-rich amyloid β peptide aggregates.
Huang Yiran Y Sun Liang L Mirica Liviu M LM
Sensors & diagnostics 20220509 4
Protein misfolding and metal dishomeostasis are two key pathological factors of Alzheimer's disease. Previous studies have shown that Cu-mediated amyloid β (Aβ) peptide aggregation leads to the formation of neurotoxic Aβ oligomers. Herein, we report a series of picolinic acid-based Cu-activatable sensors, which can be used for the fluorescence imaging of Cu-rich Aβ aggregates. ...[more]
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