Dataset Information

Association of dietary and plasma carotenoids with urinary F₂-isoprostanes.

ABSTRACT:

Purpose

Carotenoids may protect against chronic diseases including cancer and cardiometabolic disease by mitigating oxidative stress and/or inflammation. We cross-sectionally evaluated associations between carotenoids and biomarkers of oxidative stress or inflammation.

Methods

From 2003 to 2009, the Sister Study enrolled 50,884 breast cancer-free US women aged 35-74. Post-menopausal participants (n = 512) were randomly sampled to measure carotenoids and biomarkers of oxidative stress. Dietary carotenoid consumption was assessed using a validated 110-item Block 1998 food frequency questionnaire; use of β-carotene-containing supplements was also assessed. Plasma carotenoids were quantified, adjusting for batch. Urinary markers of lipid peroxidation, 8-iso-prostaglandin F_2α (8-iso-PGF_2α) and its metabolite (8-iso-PGF_2α-M) were also measured. Since the biomarker 8-iso-PGF_2α can reflect both oxidative stress and inflammation, we used a modeled 8-iso-PGF_2α to prostaglandin F_2α ratio approach to distinguish effects reflecting oxidative stress versus inflammation. Multivariable linear regression was used to assess the associations of dietary and plasma carotenoids with the estimated biomarker concentrations.

Results

Total plasma carotenoids were inversely associated with 8-iso-PGF_2α-M concentrations (P for trend across quartiles = 0.009). Inverse trends associations were also seen for α-carotene and β-carotene. In contrast, lutein/zeaxanthin showed associations with both 8-iso-PGF_2α and 8-iso-PGF_2α-M concentrations. The inverse association for total carotenoids appeared to be specific for oxidative stress (chemical 8-iso-PGF_2α; P_{highest vs. lowest quartile} = 0.04 and P for trend across quartiles = 0.02). The pattern was similar for α-carotene. However, lutein/zeaxanthin tended to have a stronger association with enzymatic 8-iso-PGF_2α, suggesting an additional anti-inflammatory effect. Supplemental β-carotene was inversely associated with both 8-iso-PGF_2α and 8-iso-PGF_2α-M concentrations, as well as with both chemical and enzymatic 8-iso-PGF_2α. Dietary carotenoids were not associated with either biomarker.

Conclusion

Plasma carotenoids and supplemental β-carotene were associated with lower concentrations of 8-iso-PGF_2α metabolite. Plasma carotenoids associations may reflect antioxidant effects.

SUBMITTER: Park YM

PROVIDER: S-EPMC9283284 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Association of dietary and plasma carotenoids with urinary F<sub>2</sub>-isoprostanes.

Park Yong-Moon Mark YM Lilyquist Jenna J Van't Erve Thomas J TJ O'Brien Katie M KM Nichols Hazel B HB Milne Ginger L GL Weinberg Clarice R CR Sandler Dale P DP

European journal of nutrition 20220307 5

<h4>Purpose</h4>Carotenoids may protect against chronic diseases including cancer and cardiometabolic disease by mitigating oxidative stress and/or inflammation. We cross-sectionally evaluated associations between carotenoids and biomarkers of oxidative stress or inflammation.<h4>Methods</h4>From 2003 to 2009, the Sister Study enrolled 50,884 breast cancer-free US women aged 35-74. Post-menopausal participants (n = 512) were randomly sampled to measure carotenoids and biomarkers of oxidative str ...[more]

PMID: 35253072

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Project description:Background: Dietary factors, such as antioxidant nutrients, contribute significantly to the maintenance of an appropriate balance between antioxidant defense and free radical production in the body.Objective: The objective of this study was to examine the relation between oxidative stress as assessed by plasma F2-isoprostane (IsoP) concentration, glycemic load (GL), glycemic index (GI), intake of antioxidant nutrients, dietary fiber, and polyunsaturated fatty acids (PUFAs).Methods: This study was a cross-sectional secondary analysis of baseline data collected from a random sample of 269 postmenopausal women participating in the Minnesota Green Tea Trial. GL, GI, and dietary variables were calculated from the diet history questionnaire. Subjects filled out surveys about the use of anti-inflammatory drugs and physical activity. Plasma IsoP concentration was assessed by GC-mass spectrometry. IsoP concentrations were compared across quartiles of GL, GI, insoluble fiber, PUFAs, and antioxidant nutrients with the use of linear regression.Results: Antioxidant supplement intake, including zinc, copper, vitamin C and vitamin E, was reported by >60% of the participants. Mean intake of PUFAs was 12.5 g. Mean plasma IsoP concentrations increased from 34 to 36.7 pg/mL in the lowest quartiles of GL and GI, respectively, to 45.2 and 41.6 pg/mL, respectively, in the highest quartiles (P-trend = 0.0014 for GL and P-trend = 0.0379 for GI), whereas mean IsoP concentrations decreased from 41.8 pg/mL in the lowest quartile of PUFAs to 34.9 pg/mL in the highest quartile (P-trend = 0.0416). Similarly, mean IsoP concentrations decreased from 44.4 pg/mL in the lowest quartile of insoluble fiber to 36 pg/mL in the highest quartile (P-trend = 0.0243) after adjustment for potential confounders.Conclusions: We concluded that dietary PUFAs and insoluble fiber are inversely associated with oxidative stress whereas GL and GI are positively associated with oxidative stress in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00917735.

Project description:BackgroundChildhood wheeze, asthma, and allergic rhinitis are common and likely have prenatal origins. Oxidative stress is associated with respiratory disease, but the association of oxidative stress during the prenatal period with development of respiratory and atopic disease in childhood, particularly beyond the infancy period, is unknown. This study aims to investigate associations between prenatal oxidative stress, measured by maternal urinary F2-isoprostanes, and child respiratory outcomes, including effect modification by maternal race.MethodsWe prospectively studied Black (n = 717) and White (n = 363) mother-child dyads. We measured F2-isoprostanes in 2nd-trimester urine (ng/mg-creatinine). At approximately age 4, we obtained parent report of provider-diagnosed asthma (ever), current wheeze, current asthma (diagnosis, symptoms and/or medication), and current allergic rhinitis (current defined as previous 12 months). We used multivariable logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) per interquartile range (IQR) increase in F2-isoprostane concentration, controlling for confounders. We examined modification by maternal race using interaction terms.ResultsThe prevalence of provider-diagnosed asthma and current wheeze, asthma and allergic rhinitis was 14%, 19%, 15%, and 24%, respectively. Median (IQR) F2-isoprostane levels were 2.1 (1.6, 2.9) ng/mg-creatinine. Associations between prenatal F2-isoprostanes and provider-diagnosed asthma, current wheeze, and current asthma were modified by maternal race. Results were strongest for current wheeze (aOR [95%CI]: 1.55 [1.16, 2.06] for White; 0.98 [0.78, 1.22] for Black; p-interaction = 0.01). We observed no association between F2-isoprostanes and allergic rhinitis.ConclusionPrenatal urinary F2-isoprostanes may be a marker associated with childhood wheeze/asthma in certain populations. Research is needed to understand underlying mechanisms and racial differences.

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Dataset Information

Association of dietary and plasma carotenoids with urinary F₂-isoprostanes.

Purpose

Methods

Results

Conclusion

Publications

Association of dietary and plasma carotenoids with urinary F<sub>2</sub>-isoprostanes.

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Association of dietary and plasma carotenoids with urinary F2-isoprostanes.

Purpose

Methods

Results

Conclusion

Publications

Association of dietary and plasma carotenoids with urinary F&lt;sub&gt;2&lt;/sub&gt;-isoprostanes.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Association of dietary and plasma carotenoids with urinary F₂-isoprostanes.

Association of dietary and plasma carotenoids with urinary F<sub>2</sub>-isoprostanes.