The association between prenatal F₂-isoprostanes and child wheeze/asthma and modification by maternal race.

ABSTRACT:

Background

Childhood wheeze, asthma, and allergic rhinitis are common and likely have prenatal origins. Oxidative stress is associated with respiratory disease, but the association of oxidative stress during the prenatal period with development of respiratory and atopic disease in childhood, particularly beyond the infancy period, is unknown. This study aims to investigate associations between prenatal oxidative stress, measured by maternal urinary F₂-isoprostanes, and child respiratory outcomes, including effect modification by maternal race.

Methods

We prospectively studied Black (n = 717) and White (n = 363) mother-child dyads. We measured F₂-isoprostanes in 2nd-trimester urine (ng/mg-creatinine). At approximately age 4, we obtained parent report of

SUBMITTER: Adgent MA 

PROVIDER: S-EPMC9414072 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature