Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis.

ABSTRACT: Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated fungal-stimulated ROS production by immune cells isolated from a population-based cohort of approximately 200 healthy individuals (200FG cohort), and mapped ROS-quantitative trait loci (QTLs). We identified several genetic loci that regulate ROS levels (P < 9.99 × 10^-6), with some of these loci being pathogen-specific, and others shared between the two fungi. These ROS-QTLs

SUBMITTER: Matzaraki V 

PROVIDER: S-EPMC9283926 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature