MRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.

ABSTRACT: The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2–naïve and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4⁺ and CD8⁺ T cells, and early CD4⁺ T cell responses correlated with long-term humoral immunity. Recall responses to vaccination in indivi

SUBMITTER: Goel RR 

PROVIDER: S-EPMC9284784 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature