GM-CSF is key in the efficacy of vaccine-induced reduction of Helicobacter pylori infection.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) colonizes the human gastric mucosa with a high worldwide prevalence. Currently, H. pylori is eradicated by the use of antibiotics. However, elevated antibiotic resistance suggests new therapeutic strategies need to be envisioned: one approach being prophylactic vaccination. Pre-clinical and clinical data show that a urease-based vaccine is efficient in decreasing H. pylori infection through the mobilization of T helper (Th) cells, especially Th17 cells. Th17 cells produce interleukins such as IL-22 and IL-17, among others, and are key players in vaccine efficacy. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing Th17 cells have been identified.

Aim

This study explores the possibility that GM-CSF plays a r

SUBMITTER: Vaillant L 

PROVIDER: S-EPMC9285700 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature