Dependency of R₂ and R₂ * relaxation on Gd-DTPA concentration in arterial blood: Influence of hematocrit and magnetic field strength.

ABSTRACT: Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R₂ ^(*) relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R₂ ^(*) versus contrast concentration relation under varying physiological and technical conditions

SUBMITTER: van Dorth D 

PROVIDER: S-EPMC9285940 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature