Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome

ABSTRACT:

Background

Pituitary stalk interruption syndrome (PSIS) is a rare disease caused by congenital pituitary anatomical defects. The underlying mechanisms remain unclear, and the diagnosis is difficult. Here, integrated metabolomics and lipidomics profiling were conducted to study the pathogenesis of PSIS.

Methods

Twenty-one patients with PSIS (BD group) and twenty-three healthy controls (HC group) were enrolled. Basal information and seminal plasma samples were collected. Untargeted metabolomics and lipidomics analyses were performed using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS).

Results

The metabolomics and lipidomics profiles of patients with PSIS changed. The prolactin signaling pathway and biosynthesis of

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9287950 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature